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Olcegepant (hydrochloride)
CAS No. 586368-06-1
Olcegepant (hydrochloride) ( BIBN-4096 hydrochloride;BIBN-4096BS hydrochloride )
产品货号. M15157 CAS No. 586368-06-1
The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥6585 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Olcegepant (hydrochloride)
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP.
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产品描述The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP; inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys (1-30mg/kg, i.v.).
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同义词BIBN-4096 hydrochloride;BIBN-4096BS hydrochloride
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通路GPCR/G Protein
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靶点CGRP Receptor
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受体CGRP Receptor
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研究领域——
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适应症——
化学信息
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CAS Number586368-06-1
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分子量906.11
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分子式C38H47Br2N9O5.HCl
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纯度>98% (HPLC)
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溶解度H2O: ≥ 66.66 mg/mL
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SMILESC1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)NC(CC4=CC(=C(C(=C4)Br)O)Br)C(=O)NC(CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6.Cl
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化学全称1-Piperidinecarboxamide, N-[(1R)-2-[[(1S)-5-amino-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-, hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Doods H, et al. Br J Pharmacol. 2000 Feb;129(3):420-3.
2. Powell KJ, et al. Br J Pharmacol. 2000 Nov;131(5):875-84.
3. Edvinsson L, et al. Eur J Pharmacol. 2002 Jan 2;434(1-2):49-53.
2. Powell KJ, et al. Br J Pharmacol. 2000 Nov;131(5):875-84.
3. Edvinsson L, et al. Eur J Pharmacol. 2002 Jan 2;434(1-2):49-53.
产品手册
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